the genetics study of gestational diabetes in iranian women and dio2 gene

introduction: gestational diabetes mellitus (gdm) is defined as abnormal glucose tolerance that is first identified or diagnosedduring pregnancy.deiodinase d2 is essential for the local production of t3 through deiodination of triiodothyroxine (t4). several polymorphisms in d2 have been described. the single-nucleotide polymorphism (snp) in d2 thr92ala is associated with decreased enzyme activity and greater insulin resistance in non-diabetic and in type 2 diabetes mellits the purpose of this study was to investigate an association of rs225014 deiodinase 2 gene polymorphism with gdm. methods: in this case-control study, 100 patients with gdm and 100 healthy control non-gdm, with mean age 29 were consecutively recruited from the endocrinology clinic of arak university of medical sciences. we analyzed d2 thr92ala polymorphism by tetra-arms pcr method. the distribution of alleles and genotypes of this polymorphism in two groupswere determined and the data were analyzed by chi-square and logistic regression analysis. results: in the 100 of case group, the frequency of tt, tc and cc genotypes of rs225014 polymorphism were 6 (6%), 82 (82%) and 12 (12%), respectively that indicated asignificant difference compared with 100 of control group: tt 10 (10%), tc 87 (87%), cc 3 (3%) (p=0.03). conclusion: the results demonstrated that homozygosis for ala/ala polymorphism has increased risk for gdm. totally, this polymorphism is significantly associated with gdm disease in iranian population as reported by previous studies.